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KMID : 0387420110220040185
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Korean Society of Oriental Neuropsychiatry
2011 Volume.22 No. 4 p.185 ~ p.199
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Nootropic and Anti-amnestic Effect of PPA on scopolamine-induced Cognitive Impairment in Mice
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Kim Soo-Hyun
Chung Dae-Kyoo
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Abstract
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In the present study, we assessed the effect of the PPA (Polygala japonica Houtt., Polygala tenuifolia WILLD. and Acorus gramineus SOLAND. mixed preparation), a traditional herbal prescription, on the learning and memory impairments induced by scopolamine. The cognition-enhancing effect of PPA was investigated using a passive avoidance test, Y-maze test and the Morris water maze test in mice. Drug-induced amnesia was induced by treating animals with scopolamine (1 mg/kg, i.p.). A single PPA (400 and 800 (mg/kg)) administration significantly reversed the scopolamine-induced cognitive impairments in the passive avoidance test (P<0.05). On the Y-maze test, PPA (400 and 800 (mg/kg)) also significantly reversed scopolamine-induced cognitive impairments in mice (P<0.05). PPA also improved escape latencies in training trials and increased swimming times and distances within the target zone of the Morris water maze (P<0.05). These results suggest that PPA attenuates amnesic state induced by scopolamine and that these Effect are mediated by enhancing the cholinergic dysfunction.
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KEYWORD
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P.P.A., Polygala japonica, Polygala tenuifolia, Acorus gramineus, Learning and memory
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